Pharmacokinetic interactions Diazepam is mainly metabolised to the pharmacologically Energetic metabolites N-desmethyldiazepam, temazepam and oxazepam. The oxidative metabolism of diazepam is mediated by CYP3A4 and CYP2C19 isoenzymes.
Oxazepam and temazepam are further more conjugated to glucuronic acid. Inhibitors of CYP3A4 and/or CYP2C19 may give increase to increased concentrations of diazepam whilst enzyme inducing medications for instance rifampicin, hypericum perforatum and particular antiepileptics can lead to considerably lowered plasma concentrations of diazepam.
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Diazepam rectal tubes can be Utilized in acute serious anxiousness and agitation, epileptic and febrile convulsions, tetanus, being a sedative in insignificant surgical and dental processes, or in other conditions where a rapid effect is required but in which intravenous injection is impracticable or undesirable.
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Description Information Sheets FAQs Reviews Supply Returns Therapeutic indications Diazepam has anticonvulsant, sedative, and muscle relaxant Qualities. It is Employed in the remedy of serious anxiety and pressure states, like a sedative and premedication, in the control of muscle mass spasm, and while in the management of Liquor withdrawal signs and symptoms. Diazepam rectal tubes may very well be Utilized in intense or disabling stress and agitation; epileptic and febrile convulsions; To ease muscle spasm caused by tetanus; being a sedative in minimal surgical and dental treatments, or other conditions during which a quick effect is needed but where by intravenous injection is impracticable or undesirable.
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